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Updated: Jun 1, 2025

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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Published on: December 19, 2018

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米托克桑通过DBD-LBD接口的结合来抑制和降低ERα

Han Wang, Yuxuan Luo, Sandeep Artham

    bioRxiv : the preprint server for biology
    |January 20, 2025
    PubMed
    概括

    一种新药,米托克桑,通过破坏其DNA结合和连接体结合域来向雌激素受体 (ER). 这种方法抑制了ER活性,克服了乳腺癌的耐药性,提供了新的治疗策略.

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