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Updated: Jun 1, 2025

Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
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氧化酸化受损导致原发性瘤脱离和转移

Emily N Arner, Erin Q Jennings, Daniel R Crooks

    bioRxiv : the preprint server for biology
    |January 20, 2025
    PubMed
    概括

    被破坏的线粒体新陈代谢,特别是氧化酸化受损,驱动上皮细胞转移到介质酶 (EMT) 和癌症转移. 抑制NDUFA4L2可以防止EMT和瘤逃逸,为转移性癌症提供新的治疗点.

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