胰岛素抵抗,认知和功能性大脑网络拓在肥胖的老年人中
Clayton C McIntyre1, Robert G Lyday2, Yixin Su3
1Neuroscience Graduate Program, Wake Forest Graduate School of Arts and Sciences, Winston-Salem, NC, USA.
bioRxiv : the preprint server for biology
|January 20, 2025
概括
外围抗胰岛素,而不是神经元,会对老年人的执行功能和海马网络产生负面影响. 这表明海马很容易受到外围胰岛素抵抗的影响.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 老年学是指老年学的学科.
背景情况:
- 肥胖与老年人的认知能力下降有关.
- 胰岛素抵抗 (IR) 是一种与肥胖和认知障碍相关的代谢功能障碍.
- 不同类型的IR与大脑功能之间的关系需要进一步研究.
研究的目的:
- 调查周围和神经元胰岛素抵抗 (IR) 与肥胖的老年人执行功能之间的联系.
- 检查外围和神经内射线与功能大脑网络拓学的关系.
- 为了确定哪种类型的IR,外围或神经元,对认知功能和大脑网络更有害.
主要方法:
- 对71名肥胖的老年人 (没有2型糖尿病) 的横截面研究.
- 使用HOMA2-IR评估外围IR;使用基于神经元衍生外体组的方法 (NDE-IR) 评估神经元IR.
- 分析了执行功能,听觉语言学习测试 (AVLT) 成绩和休息状态的功能性MRI衍生脑网络.
主要成果:
- 外围IR (HOMA2-IR) 与执行功能有负面关联.
- 神经内射线 (NDE-IR) 与执行功能或AVLT得分没有显著关联.
- 外围IR与海马网络拓学有关,但与中央执行网络无关.
结论:
- 外围红外线,但不是神经红外线,在肥胖的老年人中显示出认知和功能成像效应.
- 海马似乎特别容易受到外围红外线有害影响.
- 研究结果强调了管理周围胰岛素耐药性的重要性,以保持老年人群的认知功能和大脑健康.
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