延长释放布普伦诺芬诱导在阿片类药物不耐受的被监禁个体
Michael S Gordon1, Thomas R Blue1, Frank J Vocci1
1Friends Research Institute, Inc., 1040 Park Avenue, Suite 103, Baltimore, MD 21201, United States.
Drug and alcohol dependence reports
|January 20, 2025
概括
对于患有阿片类药物使用障碍 (OUD) 的被监禁个人来说,可以进行快速四天的语言下布普伦诺芬 (SL-B) 诱导,然后进行延长释放注射布普伦诺芬 (XR-B). 这种方法可能有助于减少监狱中的非法毒品转移.
科学领域:
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
- 刑事司法 卫生 刑事司法 卫生
背景情况:
- 在美国的惩戒设施内,布普伦诺芬维持治疗在很大程度上是无法获得的.
- 阿片类药物使用障碍 (OUD) 在监禁人口中很普遍.
- 监狱中布普伦诺芬输送的障碍包括对非法转移的担忧.
研究的目的:
- 评估一个快速的四天语言下布诺芬 (SL-B) 诱导策略的可行性.
- 评估启动延长释放注射性布普伦诺芬 (XR-B) 诱导后的安全性和耐受性.
- 提供关于在非阿片类药物耐受性囚犯中治疗OUD的数据.
主要方法:
- 一组65名在监狱中患有OUD的个人接受了为期四天的SL-B诱导.
- 在诱导开始时,参与者没有耐受阿片类药物.
- 诱导后,参与者每周接受XR-B注射,作为随机对照试验的一部分.
主要成果:
- 81.5%的参与者成功完成了为期四天的SL-B诱导.
- 53名受试者在第5天接受了第一个每周的XR-B注射.
- 15.38%的参与者报告了不良事件,大多数是轻微的;一个严重的不良事件被认为不太可能与干预有关.
结论:
- 快速的四天SL-B诱导,然后每周XR-B是一个可行的策略,监禁的个人与OUD.
- 这种诱导方法可能有助于缓解有关监狱环境中的非法布普伦诺芬转移的担忧.
- 这些发现支持在惩戒设施内实施有效的OUD治疗.
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