大脑功能网络的尺寸和地形与精神病体验,精神分裂症和双极性障碍
Daniel Mamah1, Shing Shiun Chen1, Evan Gordon2
1Department of Psychiatry, Washington University Medical School, St Louis, Missouri.
Biological psychiatry global open science
|January 20, 2025
概括
精神病体验和精神分裂症与大脑功能网络的改变有关,特别是语言和背部注意力网络. 这些发现可能有助于预测精神病并指导早期干预.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 目前对精神病的功能连接性研究依赖于人口平均的大脑网络图.
- 这些地图不考虑大脑表面网络拓的个体变化.
- 本研究涉及定义个体功能网络组织的需要及其在精神病中的变化.
研究的目的:
- 在一般人群中绘制功能性大脑网络,使用个体特定的方法.
- 调查精神病体验和障碍如何改变功能网络的地形.
- 为了确定精神病进展和干预的潜在生物标志物.
主要方法:
- 使用个人特定模板匹配在一个大队伍 (人类连接项目年轻成年人) 中生成8个功能网络的地图.
- 在精神分裂症 (SCZ) 和双相情感障碍患者中比较网络拓.
- 通过逻辑回归来评估精神病体验 (PE) 和网络概率之间的关系.
主要成果:
- 在一般人群中,PE严重程度与语言网络 (LAN) 和背部注意网络 (DAN) 区域的增加以及 cingulo-opercular 网络面积的减少相关.
- 精神分裂症与较大的DAN和LAN以及较小的前面对面网络有关.
- 具体的变化包括左上旋中增加的LAN概率和SCZ左岛中增加的视觉网络概率.
结论:
- 患有精神病和精神分裂症的个体表现出异常的功能网络拓,特别是在DAN和LAN.
- 这些独特的网络变化可以作为精神病进展的指标.
- 了解这些网络变化可以为早期治疗干预提供信息和指导.
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