校正: 肌肉缩和骨质损失在实验床上休息的反应中在实验对象之间和实验对象内部的变化
Jonas Böcker1, Marie-Therese Schmitz1,2, Uwe Mittag1
1Department of Muscle and Bone Metabolism, German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany.
Frontiers in physiology
|January 20, 2025
概括
这项研究研究了肠道微生物组在调节癌症免疫疗法的疗效方面的作用. 研究结果表明,特定的微生物组成可以显著影响治疗结果,突出潜在的治疗点.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 肠道微生物组在宿主健康和疾病中起着至关重要的作用.
- 新出现的证据将肠道微生物组成与癌症的发展和治疗反应联系起来.
- 肠道微生物群影响癌症免疫疗法的精确机制仍然不完全理解.
研究的目的:
- 研究肠道微生物群落与癌症患者免疫检查点抑制剂 (ICI) 疗效之间的关联.
- 确定与ICI治疗的积极或消极反应相关的特定细菌种群.
- 探索潜在的机制,为微生物组介导的抗瘤免疫的调节.
主要方法:
- 16S rRNA基因测序用于在ICI治疗之前和期间对癌症患者的肠道微生物组合进行分析.
- 进行了相关性分析,以将微生物多样性和丰富性与临床响应数据 (例如客观响应率,无进展生存率) 联系起来.
- 采用生物信息和统计方法来识别与治疗结果相关的关键微生物特征.
主要成果:
- 在ICI治疗的响应者和不响应者之间观察到肠道微生物多样性和组成的显著差异.
- 特定的细菌物种,如*Bacteroides fragilis*和*Akkermansia muciniphila*,在对治疗有反应的患者中得到了丰富.
- 相反,增加某些其他细菌的丰富性与反应不佳和不良事件有关.
结论:
- 肠道微生物组组成是对癌症免疫治疗反应的重要预测因素.
- 准或调节肠道微生物群是提高免疫检查点抑制剂疗效的有希望的策略.
- 需要进一步的研究来阐明因果关系,并开发用于癌症治疗的基于微生物组的干预措施.
相关概念视频
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Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...