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Updated: Jun 1, 2025

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分析阿普坦体结构和相互作用:in silico建模和仪器方法

Daria O Malysheva1,2, Maya A Dymova1, Vladimir A Richter1

  • 1Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russia.

Biophysical reviews
|January 20, 2025
PubMed
概括

简短的DNA或RNA分子aptamers对于生物传感器和药物输送至关重要. 本综述探讨了计算建模和实验方法,以了解体结构和连接体相互作用,帮助研究设计.

关键词:
在 Ab initio 建模中.亚博体育官网 亚博体育官网 亚博体育官网 亚博体育官网 亚博体育官网计算建模计算建模核磁共振光谱法 (NMR) 是一种光谱法.萨克斯 (SAXS) 的时间结构生物信息学 结构生物信息学

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Ligand Binding Sites02:40

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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