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与奥比努祖马布输液相关的反应:多中心对发生率,严重程度和危险因素的回顾性评估

Erin Hickey Zacholski^1,2, Sarah Rugh¹, Jenna Marshall¹

¹From Virginia Commonwealth University School of Pharmacy, Richmond, Virginia.

Journal of the advanced practitioner in oncology

|January 20, 2025

概括

在慢性淋巴细胞白血病/小淋巴细胞淋巴瘤 (CLL/SLL) 中,欧比努祖马布输液反应 (IRR) 是常见的. 较高的绝对淋巴细胞计数预测了IRR风险的增加,这表明需要量身定制的药物管理策略.

科学领域:

血液学血液学血液学
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

在CLL/SLL患者中,奥本图祖马布与显著的输液相关反应 (IRR) 有关.
标准的预防策略不能完全减轻IRR风险.
奥比努祖马布诱导的IRR的临床风险因素仍未确定.

研究的目的:

为了估计在现实世界CLL/SLL群体中与obinutuzumab相关的IRR的发生率.
为了确定与奥比努祖马布治疗期间IRR发展相关的临床风险因素.

主要方法:

多中心,对接受奥比努图祖马布治疗的CLL/SLL患者的回顾性评估.
分析患者数据以确定IRR发生率和相关风险因素.
变量的统计评估,包括绝对淋巴细胞计数.

主要成果:

这项研究包括68名晚期CLL/SLL患者 (平均年龄70岁,61.8%男性).
所有级别的IRR发生在25%的患者中;严重的IRR发生在1.5%.
绝对淋巴细胞数量升高是IRR发生的显著预测因素 (p ≤ .05).

结论:

在实施支持性护理措施后,现实世界中的obinutuzumab IRR率与临床试验结果保持一致.
绝对淋巴细胞计数是增加IRR风险的关键预测指标.
需要进行进一步的研究,以开发适应风险的欧比努祖马布 (obinutuzumab) 给药方案.

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