静脉瘤发病率缩短了IDH-WT质母细胞瘤的生存期
medRxiv : the preprint server for health sciences
|January 20, 2025
概括
质母细胞瘤 (GBM) 患者在诊断后面临静脉血栓栓塞 (VTE) 和肺栓塞 (PE) 的风险显著增加. 这些血栓事件与较差的生存结果有关,但不受性别的影响.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 静脉血栓栓塞 (VTE) 是癌症患者死亡的主要原因.
- 之前关于质母细胞瘤 (GBM) VTE 发病率的研究使用了有限的患者队列.
- 根据最新的世卫组织分类,需要对IDH野生型GBM患者的VTE进行大规模分析.
研究的目的:
- 系统地分析VTE发病率及其对IDH野生型GBM患者的大队伍生存的影响.
- 与非癌症患者相比,量化GBM患者的VTE/PE风险.
- 研究性别对VTE/PE风险和GBM患者的存活率的影响.
主要方法:
- 利用Trinetx数据库进行大规模的患者队列分析.
- 员工倾向得分对应人口统计学平衡.
- 应用风险比率,赔率比率,危险比率和卡普兰-梅尔曲线进行结果分析.
主要成果:
- 24%的GBM患者在诊断后至少经历过一次VTE或PE.
- 与非癌症患者相比,在1年和5年内,GBM患者的VTE/PE风险分别为20.4倍和5.96倍.
- 1年和5年的VTE/PE存活率明显恶化 (p<0.0001和p=0.0014).
结论:
- GBM患者在诊断后表现出血栓事件的风险大幅增加.
- 这些增加的风险没有性别差异,但显著影响整体存活率.
- VTE/PE是影响质母细胞瘤患者预后的关键因素.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:21Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...