1999-2020年帕金森病相关死亡率的时间趋势:国家分析
Balamrit Singh Sokhal1, Sowmya Prasanna Kumar Menon1, Thomas Shepherd1
1School of Medicine, Keele University, Keele, England, UK.
NIHR open research
|January 20, 2025
概括
帕金森病 (PD) 死亡率在美国正在上升,在年龄,性别,种族和地理区域中观察到显著的差异. 年龄较大,男性性别,白人种族和中西部地区的死亡率最高.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 帕金森病 (PD) 是神经退行性残疾的主要原因,患病率越来越高.
- 关于美国PD相关死亡率的人口趋势的数据有限.
- 对于PD患者的潜在性别和种族差异需要进一步调查.
研究的目的:
- 在20年期间分析帕金森病 (PD) 相关死亡率的国家人口趋势.
- 确定在美国不成比例地受到PD死亡率影响的特定人口群体.
主要方法:
- 利用CDC-WONDER数据库 (1999-2020年) 来获取潜在的死亡原因数据.
- 根据年龄,性别,种族和地理区域分层计算的年龄调整死亡率 (AAMR).
- 用人联结点回归来确定AAMR的年均百分比变化 (APC).
主要成果:
- 在1999年至2020年期间,发生了超过515,000起与PD相关的死亡.
- 针对PD的年龄调整后死亡率 (AAMR) 从每10万人口中的5.3增加到9.8.
- 男人,白人和中西部地区居民的PD相关死亡率较高.
结论:
- 在美国,与PD相关的死亡率存在明显的差异,跨年龄,性别,种族和地理位置.
- 年龄较大,男性性别,白人种族和中西部地区与PD死亡率增加有关.
- 调查结果强调需要有针对性的公共卫生干预措施来解决PD死亡率差异.
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