辅酶Q10可以改善精液质量和循环水平吗? 随机对照试验的系统审查和元分析
Tunmise M Akhigbe1,2, Fabrael B Fidelis2,3, Adebayo O Adekunle2,4
1Department of Agronomy, Osun State University, Ejigbo campus, Osogbo, Osun, Nigeria.
Frontiers in pharmacology
|January 20, 2025
概括
辅酶Q10 (CoQ10) 补充剂通过增加精子数量,运动性和形态学来显著改善男性生育能力. 这种抗氧化疗法也对生殖激素水平产生积极影响,支持其用于治疗男性不孕症.
科学领域:
- 生殖医学 生殖医学
- 氧化压力研究研究 氧化压力研究
- 营养补充剂 营养补充剂
背景情况:
- 精液氧化应激是男性不孕症的一个重要因素.
- 抗氧化剂治疗的有效性,如辅酶Q10 (CoQ10),对于男性不孕症仍然是有争议的.
研究的目的:
- 评估辅酶Q10补充对精液质量参数的影响.
- 为了评估CoQ10摄入后血清生殖激素水平 (,LH,FSH,抑制B) 的变化.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 在多个数据库 (Cochrane,EMBASE,PubMed/MEDLINE,Scopus,Web of Science) 搜索了符合条件的RCT.
- 分析了8个符合条件的RCT的数据,其中包括877名男性受试者.
主要成果:
- CoQ10显著增加了精子总数,总和渐进性运动性以及精子形态.
- 在接受CoQ10治疗的受试者中,血清丸激素和B抑制素水平显著更高.
- 辅酶Q10补充剂显著降低了血清LH和FSH水平.
- 没有观察到对精液量或精子度的显著影响.
结论:
- 辅酶Q10补充剂对男性的关键精液参数和生殖激素产生有益影响.
- 这些发现支持使用辅酶Q10作为男性不孕症的潜在治疗剂.
- 建议进行进一步的大规模,精心设计的RCT来证实这些结果.
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