长期COVID肺功能测试的诊断价值:对阳性支气管挑测试结果的分析
Wei Liu1, Qixuan Feng2, Xuefeng Yuan2
1First Department of Pulmonary and Critical Care Medicine, Hebei Chest Hospital, Shijiazhuang, China.
Frontiers in medicine
|January 20, 2025
概括
长期COVID患者通常具有阳性支气管挑测试 (BPT). 年龄,MEF50和DLCOc SB影响BPT阳性,但肺功能测试在这些患者中对阳性BPT的诊断价值有限.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 呼吸系统医学 呼吸系统医学
背景情况:
- 长期的COVID与支气管过敏反应和呼吸系统症状有关.
- 阳性支气管挑测试 (BPT) 在COVID后持续呼吸问题患者中很常见.
研究的目的:
- 评估长期COVID患者肺功能测试的诊断效用.
- 在COVID后的人群中确定与阳性BPT相关的因素.
主要方法:
- 在4211名COVID-19幸存者中分析BPT结果和肺功能参数 (FVC,FEV1/FVC,DLCOc SB).
- 后勤回归用于识别影响积极BPT的因素.
- 分析ROC曲线以评估诊断疗效.
主要成果:
- 80.46%的患者呈阳性BPT.
- 在BPT阳性和阴性组之间,年龄,性别,吸烟状况,FVC,FEV1/FVC和DLCOc SB的显著差异.
- 年龄,MEF50和DLCOc SB是BPT阳性的独立因素;ROC分析显示诊断值有限 (AUC<0.700).
结论:
- 年龄,MEF50 (小气道功能) 和DLCOc SB (肺扩散) 独立地影响长期COVID中的BPT阳性.
- 目前的肺功能测试和基线数据在这个队列中对阳性BPT的诊断实用性有限.
- 后COVID呼吸系统症状的复杂性需要进一步的研究超越标准的肺功能测试.
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