冠状病毒病患者住院患者的脑病变 2019:一个单中心研究
Redentor R Durano1, Ma Teresa A Cañete1
1Section of Adult Neurology, Chong Hua Hospital, Cebu Institute of Medicine.
Acta medica Philippina
|January 20, 2025
概括
COVID-19相关脑病变的发病率为0.6%,主要影响老年人,患有糖尿病和心脏病的肥胖男性. 脑病变在住院患者中显著增加死亡风险.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
背景情况:
- COVID-19 (冠状病毒疾病2019) 与各种神经系统并发症有关.
- 脑病,一种扩散性大脑功能障碍,是COVID-19患者的一个严重问题.
研究的目的:
- 为了确定住院COVID-19患者脑病变的发生率.
- 为了确定患有脑病变的COVID-19患者的风险因素和临床特征.
主要方法:
- 在菲律宾的一家三级医院住院的成年COVID-19患者的回顾性观察性研究.
- 从2020年3月到2021年9月的聚合酶连锁反应确认的COVID-19病例的完整清单.
- 根据脑病变的存在或不存在来对患者进行分类.
主要成果:
- 脑病变的发生率为每1000名住院COVID-19患者中有6名 (0.6%).
- 脑病变患者通常是老年人 (平均年龄67岁),男性,肥胖,患有2型糖尿病和冠状动脉疾病.
- 常见的表现包括呼吸不良; 实验室发现显示,禁食血糖,LDH,CRP,费里丁,公素和D-二聚合物升高.
- 脑病变与输管,感染的高炎症阶段和显著更高的死亡率 (66.7%过期) 相关.
结论:
- 脑病变发生在0.6%的住院COVID-19患者中,主要发生在患有并发症的老年男性中.
- 像脑病变这样的神经系统并发症与严重的COVID-19疾病和较差的结果有关.
- 早期识别和管理风险因素可能对改善COVID-19患者的治疗结果至关重要.
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