记忆力下降的老年人长时间夜间禁食:一组试点研究探索认知功能和心脏代谢风险因素的变化
Dara L James1, Linda K Larkey1, Molly Maxfield1
1Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, USA.
Journal of clinical and translational science
|January 20, 2025
概括
长时间的夜间禁食改善了老年人的认知功能和睡眠. 这种干预措施使饮食与昼夜节律保持一致,并有望缓解与年龄相关的认知衰退.
科学领域:
- 老年学是一门学科.
- 营养神经科学 营养神经科学
- 睡眠医学 睡眠医学
背景情况:
- 在老年人 (≥65岁) 中,认知能力下降是显著的风险.
- 需要采取干预措施来缓解与年龄相关的认知衰退及其对健康的影响.
- 与昼夜节律保持一致的间歇性禁食提供了潜在的健康益处.
研究的目的:
- 探索长达8周的夜间禁食干预对65岁以上成年人认知功能和心脏代谢风险因素的影响.
- 评估老年人自我报告记忆力下降的失眠和干预坚持的变化.
- 研究一种非药理学方法来支持老年人群的认知健康.
主要方法:
- 采用了一个单组,试点前/试点后研究设计.
- 参与者 (n=18) 进行了为期8周的干预,每晚禁食14小时.
- 这项研究是远程进行的,评估了认知功能,失眠和心脏代谢标记.
主要成果:
- 认知功能显著改善 (记忆和注意力电话选器,p=0.02) 和失眠的减少 (失眠严重程度指数,p=0.04).
- 认知和睡眠改善都显示出中等效果大小 (Cohen的d分别为0.58和0.52).
- 报告了高参与度 (66%-77%) 和坚持度 (70%-100%),但BMI或饮食质量没有显著变化.
结论:
- 长时间的夜间禁食,与昼夜节律同步,显示了提高老年人的认知功能和睡眠质量的潜力.
- 这种低成本的非药物干预措施需要在更大规模的随机对照试验中进一步调查.
- 未来的研究应该专注于确认昼夜调整的饮食模式对衰老中的认知健康的有效性.
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