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希夫基针对Sw-480结直肠细胞系:合成,表征,dS-DNA结合和抗癌研究

Hammad Nasir1, Naeem Abbas1, Muhammad Arfan1

  • 1Department of Chemistry, School of Natural Sciences, National University of Sciences and Technology Islamabad 44000 Pakistan marfan@sns.nust.edu.pk.

RSC advances
|January 20, 2025
PubMed
概括

六种新的希夫基因通过与DNA结合,证明了对结直肠癌细胞的抗瘤潜力. 化合物HSB3,HSB4和HSB1显示出强烈的活性和显著的DNA结合,表明它们的治疗前景.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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