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对精神分裂症患者轻度认知障碍的负面症状进行间歇性甲型突发刺激:一种随机控制的跟踪研究

Jing Li¹, Xian Mo², Dan Jiang³

¹Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in psychiatry

|January 20, 2025

概括

间歇性Theta爆发刺激 (iTBS) 通过增强背中前额皮层 (DMPFC) 活动,有效地减少了精神分裂症患者的负面症状. 这种神经调节技术在精神分裂症治疗方面表现有前途.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

精神分裂症的特点是负面症状和认知障碍.
背中介前额叶皮层 (DMPFC) 在认知和情绪调节中起着至关重要的作用.
通过神经调节准DMPFC可能为精神分裂症提供治疗途径.

研究的目的:

评估间歇性Theta爆发刺激 (iTBS) 在双边DMPFC对精神分裂症负面症状的疗效.
通过使用功能近红外光谱学 (fNIRS) 研究iTBS对大脑激活和功能连接的影响.
为DPFC在精神分裂症治疗中的治疗意义提供证据.

主要方法:

39名具有负面症状的精神分裂症患者被随机分配到iTBS或假治疗组.
评估包括负面症状,认知,情绪和社交功能治疗前和后随访.
使用fNIRS在口头流利任务中测量大脑激活和功能连接.

主要成果:

与假药相比,iTBS在治疗组中显著改善了负面症状评估量表 (SANS) 的得分.
在治疗后,iTBS组显示出明显更高的前额叶皮层激活和增强的小世界属性 (Sigma和Gamma).
两组之间的认知,情感或社会功能没有显著差异.

结论:

对双边DMPFC应用的iTBS有效缓解精神分裂症的负面症状.
该治疗增强了前额叶皮层的激活和功能连接.
这项研究支持DMPFC神经调节作为精神分裂症治疗的可行策略.

关键词:

背中中前额叶皮层 (DMPFC)功能近红外光谱学 (fNIRS) 是一种间歇性泰达爆发刺激 (iTBS) 是一种负面的症状负面的症状精神分裂症是一种精神分裂症.

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