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长非编码RNAFAS-AS1/FAS/Caspase3轴在子宫内膜异位症中的调制:一个横截面研究

Amir Hossein Shayanfard¹, Zivar Salehi¹, Farhad Mashayekhi¹

¹Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.

Journal of human reproductive sciences

|January 20, 2025

概括

长非编码RNAFAS-AS1可能会抑制子宫内膜异位症. 它在子宫外组织中的表达减少与子宫内膜异位症的严重程度相关,这表明它在疾病进展中的作用.

科学领域:

分子生物学分子生物学
妇科妇科妇科妇科
细胞生物学细胞生物学

背景情况:

子宫内膜异位症的发展涉及过度的细胞增殖和细胞亡.
在子宫内膜异位症发病的关键分子参与者正在调查中.

研究的目的:

评估长非编码RNA (lncRNA) FAS-AS1,FAS,可溶性Fas (sFas) 和Caspase-3在子宫内膜异位症中的表达.
为了将这些分子标记与子宫内膜异位症阶段相关联.

主要方法:

定量实时PCR用于IncRNA FAS-AS1和FAS基因表达.
在腹液中寻找sFas的ELISA.
在组织中发现分裂的caspase-3的西部斑.
在蛋白质相互作用和功能的基分析.

主要成果:

与对照组相比,子宫内膜异位症组织中的FAS和sFas表达增加 (P <0.05).
在子宫外组织中 lncRNA FAS-AS1 和分裂的caspase-3表达减少.
较低的lncRNA FAS-AS1表达与晚期子宫内膜异位症相相关.

结论:

lncRNA FAS-AS1可能会作为异位子宫内膜异位症的抑制剂.
子宫内膜异位症的严重程度与lncRNA FAS-AS1和sFAS表达水平有关.

关键词:

子宫内膜异位症是什么?子宫内膜异位症是什么?与酶相关的免疫吸收剂测定.长非编码RNA是什么意思聚合酶连锁反应的发生.

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...