在甲状腺和副甲状腺手术期间甲状腺激素波动
Emily S Sagalow1, Yuna Kim1, Shirley Wong1
1Department of Otolaryngology-Head and Neck Surgery University of Nevada Las Vegas School of Medicine Las Vegas Nevada USA.
OTO open
|January 20, 2025
概括
在接受甲状腺手术的患者中,副甲状腺激素 (PTH) 水平在全身麻醉和手术时会增加. 然而,在接受副甲状腺切除术的副甲状腺功能异常的患者中,反应有所不同.
科学领域:
- 内分泌学 在内分泌学.
- 麻醉学 麻醉学
- 手术科学 手术科学
背景情况:
- 一般麻醉和手术会提高像皮质醇和上腺素这样的压力激素.
- 甲状腺激素 (PTH) 对麻醉的反应记录在甲状腺切除术 (PT) 患者中,甲状腺功能异常,但对于正常功能患者存在相互矛盾的数据.
研究的目的:
- 研究麻醉和手术压力对PTH水平的影响.
- 在经过PT的异常副甲状腺功能患者中比较PTH反应,与经过甲状腺切除术 (单侧/全甲状腺切除术-UT/TTs) 的正常功能患者相比较.
主要方法:
- 在一个单一的高等学术中心进行了前性研究.
- 160名患者的PTH水平 (77 TT,31 UT,52 PT) 在手术前,麻醉后,手术内和术后被测量.
主要成果:
- 所有组的平均PTH水平在诱导和输管后显著增加 (TT: 113.8%的增加,UT: 128.4%的增加,PT: 34.1%的增加).
- 在切除之前,PTH仍然升高,UT患者的水平在切除后1小时内恢复到基线.
- 与甲状腺切除组相比,PT组对麻醉诱导的PTH反应更为可变.
结论:
- 麻醉和手术压力在接受UT和TT的成年人中持续提升PTH,而手术前甲状腺功能正常.
- 接受PT的甲状腺功能增强症患者在应对压力时显示出可变的PTH水平变化.
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