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Updated: Jun 1, 2025

Toeprinting Analysis of Translation Initiation Complex Formation on Mammalian mRNAs
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Toeprinting Analysis of Translation Initiation Complex Formation on Mammalian mRNAs

Published on: May 10, 2018

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工程启动tRNAs可以有效地在非AUG启动码头开始翻译,并为mRNA显示多样化N终端氨基酸

Christina Helmling1, Alix I Chan1, Christian N Cunningham1

  • 1Department of Peptide Therapeutics, Genentech, South San Francisco, CA 94080, USA.

Nucleic acids research
|January 20, 2025
PubMed
概括

这项研究探讨了使用修改的启动器tRNAs (tRNAini) 来扩展mRNA显示的遗传密码. 研究人员发现tRNA折叠影响翻译启动,但工程可以恢复库生成的功能.

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