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Updated: Jun 1, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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TRAF6通过NLRP3/Caspase1/GSDMD通路激活巨细胞灭,促进腹腔大动脉动脉瘤的发展

Huoying Cai1,2, Huaming Li3, Xiaoyong Xiao4

  • 1Department of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|January 20, 2025
PubMed
概括

瘤亡因子受体相关因子6 (TRAF6) 通过促进巨细胞灭导致腹腔大动脉动脉瘤 (AAA). 抑制TRAF6为AAA提供了一个潜在的治疗策略.

关键词:
在TRAF6中,腹部大动脉动脉瘤 腹部大动脉动脉瘤巨细胞是一个巨细胞.热致灭症是什么?

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Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions06:08

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
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