在患有多发性硬化症的患者中,自身免疫性肝炎和原发性硬化性胆管炎重叠
Marta García Calonge1, María García Martínez2, Mateo García Ramos3
1Hepatology. Gastroenterology Unit, Hospital Universitario Central de Asturias, Spain.
Revista espanola de enfermedades digestivas
|January 20, 2025
概括
本案例研究介绍了第一例被记录的原发性硬化胆管炎/自身免疫性肝炎在患有多发性硬化症的患者身上重叠的案例. 患者 患者 患者
科学领域:
- 肝病学 肝病学是一种肝病学.
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 可以与其他自身免疫性疾病共存.
- 在MS患者中,肝脏生物化学测试 (LBT) 的改变可能表明自身免疫性肝病 (AILD) 或药物诱导性肝损伤 (DILI).
- 多发性硬化与原发性硬化胆管炎 (PSC) 和自身免疫性肝炎 (AIH) 的同时发生是罕见的.
研究的目的:
- 在被诊断为MS的患者中报告PSC/AIH重叠的第一个病例.
- 讨论MS,其治疗和自身免疫性肝脏疾病的发展之间的潜在相互作用.
主要方法:
- 一个患有多发性硬化症的16岁男性的临床病例介绍.
- 监测肝脏生物化学测试 (LBT) 和自身抗体.
- 诊断程序包括肝活检 (LB) 和磁共振胆血管学 (MRC).
主要成果:
- 在开始治疗多发性硬化症的fingolimod后,患者肝酶 (ALP,GGT,AST,ALT) 升高.
- 诊断工作显示PSC/AIH重叠.
- 用ursodeoxycholic酸治疗改善了LBT,并且MS可以用natalizumab进行管理.
结论:
- 在患有多发性硬化症的患者中,PSC/AIH重叠可能会发生,这会给诊断带来挑战.
- 自免疫性肝病的病因是多因素的;MS及其疗法可能发挥作用.
- 这一案例凸显了在MS患者中考虑AILD的重要性.
相关概念视频
Autoimmune Disorders
385
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
385
Diseases of the Liver and Gallbladder
421
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
421
Chronic Bowel Disorders: Introduction
386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386
Gastritis-II: Pathophysiology
233
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
233
Chronic Pancreatitis I: Introduction
71
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
71


