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在磁共振成像后,从患者尿液中电化学过加多

Sethma Wijesinghe¹, Udeshika Weerarathna¹, Christa Kovaci¹

¹Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.

ACS applied materials & interfaces

|January 20, 2025

概括

我们开发了一种电化学过方法,在MRI扫描后从患者的尿液中提取加多 (Gd). 这种技术有效地捕捉了Gd,解决了对比剂的资源需求和环境问题.

科学领域:

环境科学环境科学
分析化学分析化学
材料科学材料科学材料科学

背景情况:

在MRI中广泛使用基于加多的对比剂 (GBCA) 导致Gd需求增加和环境污染.
直接将GBCAs排放到废水系统中会给环境带来风险.
需要有效的方法来从患者废物流中回收Gd.

研究的目的:

开发和评估一种电化学过方法,在用对比度增强的MRI后从患者尿液中提取加多 (Gd).
评估不同类型的GBCA中Gd回收的效率.
探索恢复被困Gd重复使用的方法.

主要方法:

修改具有集成电极的传统真空过装置.
在过膜上应用强电场 (∼5kV/m) 和三区pH梯度.
在过膜上以GdPO4和Gd(OH) 3形式的Gd离子的电泳分离和沉.

主要成果:

在人造和真实尿液中实现了~70%的Gd捕获效率,用于像GdDTPA这样的线性GBCA.
对宏环GBCA (例如GdDOTA) 观察到较低的效率 (~25.4%),这是由于缓慢的解离动力学.
通过在酸性条件下进行预解离,提高宏环GBCA捕获效率至40%左右.
通过热处理从真实尿样中成功地将Gd恢复为GdPO4.

结论:

电化学过是一种实用而简单的方法,可以在MRI后从尿液中恢复Gd.
这种方法既解决了对Gd日益增长的需求,也解决了环境污染问题.
恢复的Gd可以被潜在地重复使用,为这个关键元素促进循环经济.

关键词:

磁力共振成像对比剂是一种MRI对比剂.电化学过的过方法加多的回收利用方法磁共振成像技术的使用稀土元素 - - 稀土元素

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