相关实验视频
Updated: Jun 1, 2025

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
杆菌感染与便calprotectin的显著升高有关,便calprotectin是全身炎症标志物
Priscila Villalba-Davila1, Stephanie Aronson2, Jessica Lat2
1Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
杆菌 (HP) 感染会提高便中calprotectin (FC) 的水平,这是一个经常用于炎症性肠病的标志物. 在HP患者中,这种升高与接受结肠镜检查的可能性更高有关.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 儿科医学 儿科医学
背景情况:
- 便calprotectin (FC) 是诊断和监测炎症性肠病 (IBD) 的关键生物标志物.
- 中性粒细胞激活,一个增加FC的过程,也可以被像Helicobacter pylori (HP) 这样的感染所触发.
- HP感染对FC水平和随后的胃肠道 (GI) 检查的影响需要进一步澄清.
研究的目的:
- 调查HP感染对儿科患者FC水平的影响.
- 确定HP感染是否影响下游的胃肠道护理,特别是结肠镜检查的必要性.
- 评估高FC,HP感染和诊断程序之间的关系.
主要方法:
- 一项回顾性研究是使用来自纽约布鲁克林两个机构的数据进行的.
- 包括6至18岁的患者,他们在2017年1月至2022年10月期间接受了食管胃管腺镜检查 (EGD).
- 分析的数据包括FC水平 (在EGD前6个月内) 和HP测试结果.
主要成果:
- 在129名患者中,37人 (28.7%) 检测出HP感染阳性.
- 与HP阴性患者 (88.1) 相比,HP阳性患者的平均FC水平 (241.2) 显著高于HP阴性患者 (88.1) (p < 0.001).
- 升高的FC水平与接受结肠镜检查的可能性增加显著相关 (p = 0.003).
结论:
- 肝炎感染是与便中calprotectin水平升高相关的重要因素.
- 患有HP感染的患者中增加的FC水平与需要进行结肠镜检查的可能性更大相关.
- 这些发现强调了在解释儿科患者的FC水平时考虑HP感染的重要性.
更多相关视频
03:47Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
09:05High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
Published on: November 21, 2014
相关概念视频
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy