在淡水虫Cristatella mucedo中聚类体发育的转录组景观:从芽到退化
A Yu Kvach1, V A Kutyumov1, V V Starunov1,2
1Department of Invertebrate Zoology, Faculty of Biology, Saint Petersburg State University, Saint Petersburg, Russia.
概括
这项研究揭示了在淡水动物Cristatella mucedo的多种类型发育过程中的第一个转录变化. 它识别了参与芽,生长,功能和退化的关键基因通路,建议调节寿命控制.
科学领域:
- 发育生物学是发展生物学.
- 无脊椎动物动物学
- 文字转录学 (Transcriptomics) 是一个学科.
背景情况:
- 殖民地无脊椎动物的特点是短暂的模块 (动物园),对它们的整个生命周期的研究有限.
- 以前的研究集中在芽生长 (芽生殖),忽视了整个动物体生命周期.
- 这项研究解决了动物体发育和退行过程中的知识差距.
研究的目的:
- 描述在Cristatella mucedo的多种类型发育过程中的转录组变化.
- 识别与多种类型的芽,生长,功能和退化相关的基因表达模式.
- 调查潜在的调节机制,包括干性标记物和信号通路,控制多种类型的寿命.
主要方法:
- 在Cristatella mucedo中,大批量RNA测序六个不同的多种类阶段.
- 为C. mucedo.生成一个高质量的de novo参考转录组.
- 差异基因表达分析以确定丰富的途径和生物过程.
主要成果:
- 鉴定了在发育的芽和幼年多体中保存的"干细胞"标志物,尽管Bryozoa中没有先前描述的干细胞.
- 揭示了多种类型变性作为一个涉及自和编程细胞死亡的受管制过程.
- 在多种类型的发育阶段检测到了差异性基因表达,突出了关键的生物过程.
结论:
- 这项研究提供了关于C. mucedo.中的多种类型发育和退化的全面的转录学概述.
- 研究结果表明,个体动物体的寿命受到调节,可能涉及干细胞标记物和编程细胞死亡.
- 假设mTOR信号通路在调节多体寿命方面发挥着至关重要的作用.
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