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对于疟疾载体控制而言,克洛索隆和艾弗梅克丁之间潜在的相互作用.

Thitipong Hongsuwong1, Pattarapon Khemrattrakool1, Theerawit Phanphoowong2

  • 1Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

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概括
此摘要是机器生成的。

大规模对牲畜 (MITL) 进行的IVM治疗显示了通过杀死蚊子来控制疟疾的潜力. 新的IVM-chlorsulon (CLO) 配方不会影响IVM.

关键词:
这种动物叫Anopheles dirus.二硫胺是一种二硫胺.这是Clorsulon.这里是牛群.我从来没有使用过mectin.畜牧业 畜牧业 畜牧业 畜牧业宏观环形乳乳是一种蚊子 蚊子 蚊子幸存率 幸存率 生存率

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科学领域:

  • 兽医医学 兽医医学 兽医医学
  • 寄生虫学的寄生虫学
  • 医学昆虫学 医学昆虫学

背景情况:

  • 由于ivermectin (IVM) 的蚊虫致命作用,正在探索对牲畜进行大规模的甲治疗 (MITL) 来控制疟疾.
  • 目前的兽医实践越来越多地使用IVM与clorsulon (CLO) 联合配制,用于治疗牲畜虫和肝感染.
  • 在畜牧业中控制Fasciola hepatica通过减少人类暴露于肝炎而带来健康益处.

研究的目的:

  • 为了评估克洛索隆 (CLO) 对蚊的生存率的直接影响.
  • 为了确定CLO是否会改变ivermectin (IVM) 的蚊虫杀伤功效.
  • 通过MITL评估IVM-CLO联合配方对疟疾载体控制的影响.

主要方法:

  • 蚊子通过血液食暴露于不同度的CLO (1-10,000 nM),并监测其存活时间10天.
  • 同时养的实验涉及An. 在IVM (4和6 ng/mL) 养的血液中,有或没有CLO,其度模拟牛峰值 (Cmax) 和Cmax的五倍.
  • 在所有实验组中,蚊子的存活率在养后的10天内被评估.

主要成果:

  • 单独CLO在测试度下对Anopheles dirus蚊子没有致命影响.
  • 与CLO同时使用IVM并没有改变IVM的蚊虫杀伤效果.
  • 在MITL中IVM对蚊子控制的有效性不太可能受到CLO在共同配方中的存在的影响.

结论:

  • 克洛苏隆不具有直接的蚊虫杀伤性,也不会干扰ivermectin对蚊子的疗效.
  • 目前在牲畜中使用的IVM-CLO联合配方与MITL用于疟疾载体控制的使用兼容.
  • 麻省理工学院与IVM-CLO一起提供了对畜牧业寄生虫控制和潜在的疟疾传播减少的双重好处,与One Health原则保持一致.