在乙型肝炎疫苗接种后的长期免疫力和记忆回应:系统性审查和元分析
Hannah Ramrakhiani1,2, Michael H Le3, Leslie Kam1
1Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, California, USA.
Journal of viral hepatitis
|January 20, 2025
概括
乙型肝炎病毒 (HBV) 免疫持久性和对复发疫苗接种的历史回应在分析中进行了评估. 大约63%的人在10年后仍然保持免疫力,对增强剂的反应率更高.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 儿童接种乙型肝炎病毒 (HBV) 疫苗对于长期保护至关重要.
- 了解HBV免疫的持久性和对强剂的反应对于公共卫生战略至关重要.
- 以前的研究表明,在儿童接受HBV疫苗接种后,长期免疫力的结果各不相同.
研究的目的:
- 为了确定在儿童或青少年时期接种疫苗的个体中乙型肝炎病毒 (HBV) 免疫力的持久性.
- 评估该人群中对HBV疫苗增剂剂的历史反应的患病率.
- 为了确定影响HBV免疫耐久性和史学反应的因素.
主要方法:
- 系统审查和对2023年6月1日之前发表的研究进行元分析.
- 包括91项符合条件的研究,包括来自208个队伍的193,359名个人.
- 排除具有重大并发症或不到5年的随访期的研究.
主要成果:
- 63.2%的人在平均后续10.15年后保持了HBV免疫力.
- 每个随访年,HBV免疫力下降6.62%,接种疫苗时的年龄较小与更好的免疫保留有关.
- 对强剂的历史反应率为90.34%,研究环境是一个独立的因素.
结论:
- 在儿童疫苗接种10年后,HBV免疫率大约为60%.
- 高的记忆回应率 (约90%) 表明免疫记忆被保存.
- 考虑对具有远距离疫苗接种史的高风险个人进行HBV免疫测试,并根据需要给药.
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