雄激素差异调节葡萄糖皮质体对脂肪组织和肌肉质量的影响
The Journal of endocrinology
|January 20, 2025
概括
雄激素不会直接导致葡萄糖皮质醇的代谢变化,但它们确实会影响组织的反应. 雄激素信号调节葡萄糖皮质体对瘦身和脂肪质量的作用,以特定于组织的方式.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 分子生物学分子生物学
背景情况:
- 葡萄糖皮质类药物和雄激素在代谢调节方面已知相互作用.
- 雌激素可以增强葡萄糖皮质激素诱导的胰岛素抵抗和脂肪积累在雄性小鼠.
- 雄激素受体 (AR) 的直接作用和组织特异性影响仍然不清楚.
研究的目的:
- 为了研究雄激素对葡萄糖皮质体信号传递的影响.
- 为了确定雄激素缺乏和补充对葡萄糖皮质激素作用的组织特异性影响.
- 评估雄激素受体 (AR) 对葡萄糖皮质醇介导的代谢变化的直接贡献.
主要方法:
- 利用兰花切除术和化学割模型在雄性小鼠中进行雄激素剥夺.
- 服用二测试 (DHT) 和皮质 (CORT),有或没有雄激素信号.
- 采用了全球AR敲除小鼠,并在暴露于CORT时对野生类型 (WT) littermates进行了比较.
主要成果:
- 单独的DHT增加了肌肉质量,但没有影响脂肪质量;CORT增加了脂肪质量,减少了肌肉质量.
- 同时补充DHT可以抵消CORT对瘦肉质的影响,但可以增强其对脂肪的作用.
- 脂肪组织中的葡萄糖皮质激素诱导的基因表达在某些组织中依赖于雄激素,但在其他组织中却不依赖于雄激素;AR淘汰小鼠的CORT代谢反应与WT小鼠相似.
结论:
- 功能性雄激素受体 (AR) 信号传递对于葡萄糖皮质体的代谢作用并不重要.
- 雄激素信号以组织依赖的方式影响葡萄糖皮质类药物反应,反对瘦体质量损失,促进脂肪质量增加.
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