和的暴露与骨矿物质密度的增加有关
Jihui Wang1, Xiyan Zhang2, Yuzhuo Zeng2
1Department of Orthopedics, The Fifth People's Hospital of Jinan, Jinan, 250000, China. jihui0920@163.com.
概括
这项研究发现,接触某些金属,如,和,与较高的骨矿物质密度 (BMD) 有关. 金属相互作用,特别是尿液中的和锡,对BMD表现出协同作用.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 骨矿物质密度 (BMD) 对骨健康至关重要,但其与人体金属暴露的关系尚未得到充分研究.
- 了解金属暴露对BMD的影响对于公共卫生和预防策略至关重要.
研究的目的:
- 在人类群体中调查各种金属暴露与骨硬化之间的关联.
- 探索金属之间的潜在相互作用和它们对骨的联合作用.
主要方法:
- 来自中国东部的159名参与者提供了尿液和血液样本,用于使用诱导合等离子体质谱 (ICP-MS) 进行金属分析.
- 使用了包括二进制物流回归 (BLR),通用线性模型 (GLM) 和贝叶斯内核机器回归 (BKMR) 在内的统计模型.
- 分析了六种特定金属 (Mn,Co,As,Se,Mo,Cd) 与骨硬度的相关性,并关注相互作用.
主要成果:
- 在尿 (As), (Mo), (Se) 和锡 (Sn) 与BMD之间观察到显著的正相关性.
- 五种金属 (Mn,Co,As,Se,Mo) 在血液和尿液中都显示出强烈的相关性.
- BKMR模型揭示了尿 (Mo) 和锡 (Sn) 之间的协同效应,表明联合暴露增加了BMD.
结论:
- 接触金属,包括,,和锡,与人类的骨矿物质密度增加有关.
- 和锡等金属之间的协同作用强调了在骨健康研究中考虑联合暴露的重要性.
- 需要进一步的研究,以阐明金属骨相互作用对整体骨健康的机制和影响.
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