连接点: 低度的尾粘膜性瘤和尾中的状息肉
Juhi Devendra Mahadik1, Naziheh Assarzadegan1
1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, United States.
American journal of clinical pathology
|January 20, 2025
概括
状息肉 (SP) 和低度尾粘膜性瘤 (LAMN) 分享KRAS突变和重叠特征,表明生物连续性. 仔细的组织病理学和分子评估对于准确的诊断至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 低度的尾粘膜性瘤 (LAMNs) 和状多体 (SPs) 是尾瘤.
- 这两个实体都可能表现出KRAS突变和重叠的形态特征,使诊断复杂化.
研究的目的:
- 调查LAMNs和附录中的SP之间的关系.
- 确定这些尾瘤之间的共同特征,包括形态和分子特征.
主要方法:
- 从档案记录中对27个LAMN和24个SP案件进行了回顾性分析.
- 选择病例的组织病理学审查和分子分析 (KRAS突变).
- 根据诊断标准重新分类病例.
主要成果:
- 在29.6%的LAMN中观察到有状结构,类似于超塑性息肉,状状病变 (SSL) 或传统的状腺瘤 (TSA).
- 与LAMN的形态重叠在12.5%的SP中被观察到,其特点是粘膜,平坦的粘膜和腺瘤样特征.
- KRAS突变在有状结构的LAMN (100%),经典的LAMN和患有发育不良的SP中普遍存在.
结论:
- 附录SP和LAMN可能代表生物连续.
- 共同的KRAS突变和形态重叠支持这种连续性.
- 准确的诊断需要细致的病原体和分子评估.
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