奥兰扎/萨米多芬对体重增加的影响:对第2期和第3期随机双盲研究的个人患者数据的元分析
Christoph U Correll1,2,3, Michael J Doane4,5, David McDonnell6
1Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, New York.
The Journal of clinical psychiatry
|January 20, 2025
概括
与单独使用 olanzapine 相比,olanzapine 和samidorphan (OLZ/SAM) 的组合在12周内在患有精神分裂症或双相I型精神障碍的患者中显示体重增加减少.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 体重增加是 olanzapine 治疗的一个显著副作用.
- 管理体重增加对于患者的坚持和精神病治疗中的整体健康至关重要.
研究的目的:
- 为了比较与 olanzapine 和 samidorphan (OLZ/SAM) 联合治疗与 olanzapine 单一治疗相关的体重变化.
- 评估OLZ/SAM在减轻奥兰zapine诱导的体重增加方面的有效性.
主要方法:
- 3个随机临床试验的个人患者数据 (IPD) 分析.
- 包括患有精神分裂症或双相I型精神障碍的成年患者,接受OLZ/SAM或 olanzapine至少12周.
- 主要结局:12周体重百分比变化;次要结局:体重增加≥7%或≥10%的患者比例.
主要成果:
- 对1063名患者的分析表明,OLZ/SAM与12周的奥兰扎宾相比,与更低的平均百分比体重变化 (-1.75%的差异) 相关.
- 在OLZ/SAM治疗的患者中,较少的患者经历了≥7%的体重增加 (23.9%与34.6%) 或≥10%的体重增加 (13.7%与20.4%) 与 olanzapine 相比.
- 这些发现具有统计学意义,赔率比率表明OLZ/SAM减轻了体重增加的风险.
结论:
- 在12周的时间内,OLZ/SAM组合治疗显著减少体重增加,相比单独使用 olanzapine.
- 在接受 olanzapine 治疗的患者中,OLZ/SAM 提供了一种潜在的治疗选择,用于管理与体重相关的不良反应.
- 这些发现支持OLZ/SAM的使用,以改善精神疾病的治疗坚持和治疗结果.
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