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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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一个新的基于智能手机的认知查电池用于多发性硬化症 (认知):验证研究.

Stijn Denissen1,2, Delphine Van Laethem1,3, Johan Baijot1

  • 1AIMS Lab, Center for Neurosciences, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Journal of medical Internet research
|January 20, 2025
PubMed
概括

智能手机iCognition应用程序有效地选多发性硬化症 (MS) 患者的认知衰退,评估记忆和处理速度. 这个工具提供了一个有效的,远程替代传统的,耗时的纸质测试.

关键词:
认知 认知 认知信息处理速度信息处理速度.记忆 记忆 记忆 记忆 记忆手机电话 手机电话手机电话多发性硬化症多发性硬化症远程医疗远程医疗

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科学领域:

  • 神经学 神经学
  • 数字健康数字健康
  • 认知科学 认知科学

背景情况:

  • 认知能力的恶化是多发性硬化症 (MS) 的一个重大挑战,需要频繁的临床监测.
  • 目前的纸和笔认知测试对于常规临床使用来说是耗时和昂贵的.
  • 基于智能手机的远程医疗工具显示出MS远程监测的可行性和接受性,但现有的应用程序往往缺乏记忆评估,容易受到运动干扰.

研究的目的:

  • 验证iCognition智能手机应用程序作为查MS患者认知恶化的工具.
  • 评估iCognition电池检测内存和信息处理速度的变化的能力.
  • 为了确定认知测试的并发有效性,测试重试可靠性和临床相关性.

主要方法:

  • 图像识别电池包括三个测试:符号测试 (信息处理速度),点测试 (视觉空间内存) 和视觉倒数数字跨度 (vBDS,工作内存).
  • 通过将认知测试与它们的纸和笔等价物 (符号数字模式测试,10/36空间回忆测试,听觉倒数数字跨度) 进行比较来评估有效性.
  • 101名多发性硬化症患者和82名健康对照参与了这项研究;一组对照进行了重复测试以评估可靠性. 还检查了与扩展残疾状况尺度的相关性.

主要成果:

  • 所有的图形认知测试都与它们的纸和笔对应物显示出强烈的相关性,这表明它们具有良好的并发有效性.
  • 这些测试表现出中度的测试-重试可靠性,类内相关系数 (ICC) 从0.71到0.74.
  • 在MS患者和健康参与者之间,识别测试的表现与金标准纸和笔测试的结果相似.

结论:

  • 智能手机iCognition应用程序是用于MS患者远程认知查的经过验证的工具.
  • 未来将整合到一个数字健康平台,将认知评估与脑成像和患者报告的结果相结合.
  • 建议进行进一步的研究,以证实在现实世界中远程设置中的图形认知的可用性和心理特征.