对单独的hCG触发器与双重触发器在体外受精后实现活产的成本分析
Reproduction & fertility
|January 20, 2025
概括
在体外受精 (IVF) 过程中,添加 gonadotropin释放激素激素激素 (GnRHa) 与人类胆管性激素 (hCG) 一起,可显著提高活产率13%,额外成本最小,这被证明是一个成本有效的策略.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
背景情况:
- 人体胆管性腺激素 (hCG) 是IVF中最终卵细胞成熟的标准触发剂.
- 人们对添加性腺激素释放激素激动剂 (GnRHa) 作为共同触发剂的成本效益存在担忧.
研究的目的:
- 评估使用GnRHa与hCG (双触发) 结合使用的成本效益与单独使用hCG在IVF中触发卵细胞成熟.
主要方法:
- 开发了一个成本模型来比较双触发和仅hCG的策略之间的活产率 (LBRs) 和相关成本.
- 该模型分析了每百分点增加LBR的增量成本.
主要成果:
- 双触发策略导致LBR增加了13%.
- 双触发策略的附加成本为175美元,相当于LBR每1%增加13美元.
结论:
- 作为双触发剂的GnRHa和hCG的组合是一种提高试管婴儿成功率的经济有效方法.
- 最小的成本增加是由于活产率的显著改善而得到证明的.
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