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在儿童急性淋巴细胞白血病 (ALL) 中,对6-美卡普图 (6-MP) 的坚持和习惯强度
Mira Muxi Yang1, Revika Singh1, Maureen Haugen2
1Department of Medical Education, Northwestern University Feinberg School of Medicine, Chicago, USA.
在儿科急性淋巴细胞白血病 (ALL) 中,对6 - 默卡普托普林 (6-MP) 的低坚持是常见的. 习惯强度与6-MP坚持不相关,这表明需要其他干预措施.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在儿科急性淋巴细胞白血病 (ALL) 中,对6 - 默卡普托普林 (6-MP) 的低坚持与更高的复发率有关.
- 习惯形成以前与改善药物坚持有关.
研究的目的:
- 调查6 - 默卡普托普林 (6-MP) 坚持,习惯强度和儿科ALL患者与健康相关的生活质量之间的关系.
- 为了确定影响这群人群遵守6MP治疗的因素.
主要方法:
- 这是一项涉及52名参与者 (11名患者,41名家长/照顾者) 的横截面研究.
- 通过视觉模拟量表 (VASdose),药物坚持量表和自我调节习惯指数 (SRHI) 收集的数据.
- 通过专题分析分析的半结构面试.
主要成果:
- 81%的参与者报告了高的6-MP坚持 (≥95%).
- 在坚持和习惯强度之间没有观察到显著的相关性.
- 促进者包括提醒和社会支持;障碍包括财务负担和安排冲突.
结论:
- 儿童ALL患者的很大一部分表现出低6MP坚持,独立于习惯强度.
- 日常生活中的变化可能会阻碍6MP服用时的自动性发展.
- 专注于习惯形成策略的干预措施可能有助于克服坚持障碍并改善治疗结果.
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