肥胖和大脑皮层厚度之间的遗传关联:综合遗传相关性,多路径元分析和孟德尔随机化
Jiankun Chen1,2, Simin Pan2, Yingfei Tan3
1State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences), Guangzhou, China.
Neuroendocrinology
|January 20, 2025
概括
与肥胖相关的特征,如体重指数 (BMI),与减少大脑皮层厚度有遗传联系. 这表明肥胖可能会影响大脑结构并导致神经精神疾病.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 肥胖与认知障碍和神经精神疾病有关.
- 大脑皮层厚度的变化与这些情况有关.
- 肥胖和皮层厚度之间的遗传联系尚未完全理解.
研究的目的:
- 为了研究与肥胖相关的特征和大脑皮层厚度之间的遗传关系.
- 为了确定与肥胖和皮层厚度相关的遗传位置.
- 为了确定肥胖是否会对大脑皮层厚度产生因果影响.
主要方法:
- 利用来自欧洲祖先群体的大规模基因组广泛关联研究 (GWAS) 总结统计数据.
- 分析了体重指数 (BMI),腰比 (WHR) 和BMI调整的WHR (WHRadjBMI) 以及大脑皮层厚度.
- 采用了遗传相关性,多特征元分析和门德尔随机化.
主要成果:
- 在BMI和皮层厚度 (rg = -0.0542,p = 0.0435) 和WHR和皮层厚度 (rg = -0.0744,p = 0.009) 之间发现了显著的遗传相关性.
- 鉴定出了连接肥胖特征的三个遗传位置.
- 门德尔的随机化支持BMI,WHR和WHRadjBMI在减少皮层厚度方面的因果作用.
结论:
- 遗传预测的与肥胖相关的特征因果关系地影响了大脑皮层厚度的减少.
- 提供了将肥胖与大脑结构变化联系起来的遗传证据.
- 表明肥胖可能通过改变皮质厚度导致神经精神疾病.
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