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原发性硬化性脑膜炎和克罗恩病之间的患病率和双向关联:系统性审查和元分析
Dongyuan Zheng1, Qinke Xu1, Jin Wu1
1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Gastroenterologia y hepatologia
|January 20, 2025
概括
这项研究发现克罗恩氏病 (CD) 和原发性硬化性胆道炎 (PSC) 之间存在显著联系. 在患有PSC的女性中,CD比男性更常见,这突出了重要的流行病学联系.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 原发性硬化性脑膜炎 (PSC) 和克罗恩病 (CD) 是具有重叠特征的慢性炎症状况.
- 了解PSC和CD之间的流行病学关系对于患者管理和研究至关重要.
研究的目的:
- 评估原发性硬化性脑膜炎 (PSC) 患者中克罗恩病 (CD) 的患病率.
- 评估患有克罗恩病 (CD) 的患者中原发性硬化性胆道炎 (PSC) 的发生率.
- 为了确定PSC和CD之间的相互关系.
主要方法:
- 在PubMed和Embase数据库中进行了全面的文献搜索,直到2023年12月.
- 包括的研究报告了PSC患者中CD的患病率或CD患者中PSC的患病率.
- 使用德西莫尼安和莱尔德方法与弗里曼-图基转换进行的元分析;使用乔安娜·布里格斯研究所检查清单评估研究质量.
主要成果:
- 在CD患者中PSC的患病率为0.88%.
- 在PSC患者中CD的患病率为11.27%,女性患病率 (13.05%) 比男性 (10.71%) 高.
- 与男性PSC患者相比,女性PSC患者的CD患病率较高.
结论:
- 在PSC和CD之间存在显著的双向关联.
- 患有PSC的女性患者中,CD的患病率显著更高.
- 这些流行病学发现对于临床实践和未来的研究方向都很重要.
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