在超分支聚合物上加载黄素,Zeen通过基因点击反应发挥作用,成为用于化疗和光动力疗法的pH响应药物递送系统
Meiying Liu1, Tongsheng Huang1, Yiping Liu2
1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
International journal of biological macromolecules
|January 20, 2025
概括
这项研究引入了一种基于Zain的新型药物递送系统,该系统使用高分支聚合物 (HPG) 实现功能. 该系统有效地封装了黄素 (CUR),并证明了对pH反应的释放,增强了癌症治疗潜力.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 扎因蛋白显示出药物输送的前景,但其稳定性和释放控制性较差.
- 现有的基于Zain的系统面临着诸如低封装效率和快速初始药物释放等挑战.
研究的目的:
- 为抗癌剂黄素 (CUR) 开发一种稳定可控的基于Zain的药物输送系统.
- 为了提高Zain的药物载荷能力,体稳定性,并实现pH响应的药物释放.
主要方法:
- 用终端基超分支聚合物 (HPG) 功能化Zeen,以创建Zeen-HPG-PA.
- 通过基因点击反应将CUR加载到Zeen-HPG-PA上,形成Zeen-HPG-PA@CUR.
- 评估药物负载,颗粒大小,水分散性,释放动力学和细胞毒性.
主要成果:
- Zein-HPG-PA@CUR表现出高的药物载荷能力,小颗粒大小和出色的水分散性.
- 最小的CUR释放发生在pH7.4时,在酸性环境中观察到逐渐释放.
- 与自由CUR相比,Zain-HPG-PA@CUR在照射光线时显示出对MDA-MB-231细胞的增强细胞毒性.
结论:
- 超分支聚合物功能化显著改进了基于Zain的药物输送系统.
- 开发的Zain-HPG-PA@CUR系统为响应性癌症治疗提供了一个有前途的平台.
- 这项工作推进了Zain在制造先进的响应性药物输送系统方面的应用.
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