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丹古伊尼安通可以通过调节PI3k/AKT信号通路来减轻突纤维化

Qing Liao¹, Shuang Wu², Xiao Li²

¹Traditional Chinese Pharmacological Laboratory, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510000, China.

Journal of ethnopharmacology

|January 20, 2025

概括

丹古伊宁通 (Danggui Niantong Decoction,DGNTD) 通过减少炎症标志物和调节PI3K/AKT通路来缓解骨关节炎疼痛和纤维化. 这种传统中医药为骨关节炎管理提供了一个新的治疗途径.

科学领域:

传统中国医药传统中国医药
药理学药理学是指药理学的学科.
骨关节炎研究骨关节炎研究

背景情况:

丹古伊宁通 (Danggui Niantong Decoction,简称DGNTD) 是一种用于治疗类风湿性关节炎和骨关节炎 (OA) 的传统中医配方.
甲状腺综合体的特征是炎症,纤维细胞样同胞细胞 (FLS) 增殖和纤维化,导致疼痛和硬.
在OA synovium中DGNTD的确切机制尚不清楚.

研究的目的:

为了阐明DGNTD对OA synovium的影响.
研究DGNTD在OA中的作用的潜在分子机制.

主要方法:

液态染色体质谱法 (LC-MS) 确定了DGNTD成分.
鼠类FLS和OA动物模型 (ACLT/MMx) 用于评估DGNTD对突炎和纤维化的影响.
进行了蛋白质组学和基因表达分析 (mRNA).

主要成果:

在DGNTD中,LC-MS检测到322个组件.
在体内研究表明,DGNTD减少了OA疼痛,突炎症和纤维化,降低了CGRP,iNOS,α-SMA和Col3a1.3等标志物.
在TGF-β诱导的FLS中,DGNTD抑制了亲炎性和纤维性基因表达,涉及PI3K/AKT通路.

结论:

通过调节PI3K/AKT信号通路,DGNTD可以部分缓解OA疼痛,肌炎和纤维化.
这些发现为OA机制和DGNTD的治疗潜力提供了见解.
为使用DGNTD在OA临床管理中提供了理论和实验基础.

关键词:

丹古伊宁通 (DGNTD) 的制品纤维细胞类同胞细胞类似于纤维细胞.骨关节炎是一种骨关节炎.突纤维化突纤维化综合性炎症综合性炎症

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