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在Lepidium sativum种子中的黄类糖化物及其生物活性

Yergazy Shybyray¹, Liu Liu², Haiqing Zhao²

¹State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi, 830011, Xinjiang, China; University of Chinese Academy of Sciences, Beijing, 100039, China; The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, al-Farabiave. 71, Almaty, 050040, Kazakhstan.

|January 20, 2025

概括

从Lepidium sativum种子中发现了五种新的黄类糖化物,即lepisativutimines Q-U. 一些化合物显示出潜在的抗糖尿病和抗炎活性.

科学领域:

自然产品化学自然产品化学
药理学是指药理学,即药理学是指药理学.
药用化学医学化学

背景情况:

莱皮迪乌姆 (Lepidium sativum) (花园) 的种子是生物活性化合物的来源.
黄类糖化物代表了一类具有多样化药理性质的天然产品.

研究的目的:

从Lepidium sativum种子中分离和表征黄类糖化物.
调查分离的化合物的抗糖尿病和抗炎活性.

主要方法:

使用染色学和光谱技术 (NMR,MS) 来分离和阐明化合物的结构.
通过酸解,衍生和GC分析来确定糖的绝对配置.
试验室试验评估抑制PTP1B,α-葡萄糖酶和氧化 (NO) 释放的抑制活性.

主要成果:

鉴定出了12种黄类糖化物,其中包括5种新型化合物 (lepisativutimines Q-U).
描述了两种不常见的kaempferol 8-S-glycosides,并为beitingxinhuangtong A.提供了完整的NMR数据.
几种化合物表现出不同程度的抗糖尿病活性 (PTP1B和α-葡萄糖酶抑制) 和抗炎活性 (NO释放抑制).

结论:

莱皮迪亚姆 (Lepidium sativum) 种子含有丰富多样性的黄类甘油酸.
特定的化合物,如奎尔塞-7-O-α-l-rhamnopyranoside,显示出抗糖尿病应用的巨大潜力.
这项研究提供了关于Lepidium sativum的化学成分和生物活性的宝贵见解,支持其民族植物学用途.

关键词:

活动活动活动.这种植物是Brassicaceae.黄类糖化物黄类糖化物黄类糖化物隔离和结构识别.莱皮迪亚木 (Lepidium sativum) 的种子质量碎片化的途径.

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