单细胞真核生物paramecium模型的多重生物反应和转录组可塑性,对的毒性加剧了淡水酸化
Congjun Li1, Haitao Wang1, Yu Fu1
1Laboratory of Marine Protozoan Biodiversity and Evolution, Marine College, Shandong University, Weihai, China.
Environmental pollution (Barking, Essex : 1987)
|January 20, 2025
概括
淡水酸化 (FA) 增加了 (Cd) 的生物积累和毒性,使 (Cd) 的污染恶化,在水生生物中增加了 (Cd) 的生物积累和毒性. 这种相互作用影响细胞功能和能量代谢,影响淡水食物网的基础.
科学领域:
- 环境毒理学环境毒理学
- 水生生态学 水生生态学
- 细胞生物学 细胞生物学
背景情况:
- (Cd) 污染对水生生态系统构成重大威胁.
- 淡水酸化 (FA) 是一个持续的环境压力因素.
- 对于Cd污染和FA对水生生物的综合影响尚不清楚.
研究的目的:
- 调查淡水酸化对生物毒性的影响.
- 在酸性条件下探索模型状植物Paramecium tetraurelia对Cd的反应.
主要方法:
- 使用了模型状动物Paramecium tetraurelia.
- 在模拟酸性化过程中,暴露于环境相关度Cd的毛动物.
- 分析了Cd生物积累,生物可用性,细胞应激指标 (溶酶体稳定性,氧化应激),ATP水平和基因表达 (转录组分析).
主要成果:
- 酸性淡水加速了Cd的生物积累,并提高了其在P. tetraurelia中的生物利用性.
- 同时暴露于Cd和FA减少了状细胞的丰富性和生物量,破坏了 lysosomal 稳定性,诱导了氧化应激,并增加了ATP消耗.
- 转录组分析显示了适应性反应,包括运输/排毒基因的上调和能量代谢基因的下调.
结论:
- 淡水酸化加剧了毛动物中的毒性.
- 类动物表现出适应性转录反应,以应对Cd和FA的联合压力,可能从生长中转移能量.
- 这项研究提供了关于Cd污染和FA在淡水食物网的基础上的相互作用的机制性见解.
更多相关视频
09:01A High-throughput Assay for the Prediction of Chemical Toxicity by Automated Phenotypic Profiling of Caenorhabditis elegans
Published on: March 14, 2019
7.2K
07:28A Toxicological and Ecotoxicological Assay Based on Mussel (Mytilus galloprovincialis) Hemocytes Motility
Published on: December 13, 2024
342
相关概念视频
02:02Responses to Salt Stress
13.0K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
13.0K
01:10Transcription
146.5K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
146.5K
01:57Adaptations that Reduce Water Loss
25.1K
Though evaporation from plant leaves drives transpiration, it also results in loss of water. Because water is critical for photosynthetic reactions and other cellular processes, evolutionary pressures on plants in different environments have driven the acquisition of adaptations that reduce water loss.
25.1K