基于软纳米粒子的平台在人类和兽医三虫病治疗的进展:一个范围审查
Raul Edison Luna Lazo1, Fernando Miguel Stelmach Alves1, Eric Luiz Domingos1
1Centro de Estudos em Biofarmácia, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.
概括
软纳米基药物输送系统显示出治疗人类和动物的Trichomonas阴道感染的前景. 在人类临床试验开始之前需要进一步的临床前研究.
科学领域:
- 制药科学 制药科学
- 传染性疾病 传染性疾病
- 材料科学 材料科学 材料科学
背景情况:
- 由Trichomonas vaginalis引起的三菌,对健康和经济造成重大负担.
- 现有的治疗方法面临挑战,需要新的药物输送策略.
- 一个健康的方法对于解决人类和动物感染都很重要.
研究的目的:
- 进行针对抗Trichomonas vaginalis药物的基于软材料的药物递送系统的范围审查.
- 分析这些配方的物理化学性质,体外/体内评估和挑战.
- 探索人类三虫病和相关动物感染 (牛,家禽) 的应用.
主要方法:
- 在PubMed,Scopus和Web of Science的系统文献搜索到2024年5月.
- 根据资格标准,从103篇获取的文章中包含18项研究.
- 专注于软纳米粒子配方 (聚合物,基于脂质) 在局部应用 (水凝,薄膜).
主要成果:
- 软纳米颗粒配方,包括水凝和聚合物薄膜,被研究了抗trichomonas活性.
- 讨论了物理化学特征和毒理学概况.
- 配方在妇科和动物感染方面表现有前途,主要在动物模型中进行评估.
结论:
- 软纳米基配方是有前途的治疗候选者.
- 关于人体应用和临床翻译存在重大知识差距.
- 在进入人类临床试验之前,进一步的临床前测试是必不可少的.
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