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作为牙周炎和慢性病之间的可能联系:一个横截面研究
Sri Vidhya Marimuthu1, Devi Arul1, Muthukumar Santhanakrishnan1
1Department of Periodontology, Sri Ramachandra Dental College and Hospital, Chennai, India.
Journal of Yeungnam medical science
|January 20, 2025
概括
Salivary Galectin-3 (Gal-3) 是一种有价值的慢性牙周炎和慢性病 (CKD) 的早期诊断标记物. 较高的Gal-3水平表明这些炎症状况之间存在强烈的关联.
科学领域:
- 口腔健康 口腔健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物发现发现
背景情况:
- 慢性牙周炎与全身炎症和各种疾病有关.
- 关于慢性牙周炎与慢性病 (CKD) 相关性的研究有限.
- 系统性炎症是这两种疾病进展的关键因素.
研究的目的:
- 测量患有牙周炎和CKD的患者的唾液中加勒-3 (Gal-3) 水平.
- 了解唾液Gal-3,牙周炎和CKD之间的关联.
- 评估Gal-3作为这些疾病的潜在诊断生物标志物.
主要方法:
- 75名患者被分为三个组:带有牙周炎的CKD,仅有牙周炎和仅有CKD.
- 收集了人口,牙周和脏的参数.
- 用酶相关的免疫吸收试验量化了唾液中的Gal-3水平.
主要成果:
- 患有慢性牙周炎的患者 (有或没有CKD) 与单独患有CKD的患者相比,唾液中的Gal-3水平显著更高.
- 在所有组中,在临床参数和Gal-3水平之间观察到强烈的相关性.
- 在患有同时存在慢性牙周炎和CKD的患者中,唾液中的Gal-3水平显著升高.
结论:
- 唾液中的加勒-3 (Gal-3) 作为一种有价值的早期诊断标记物.
- -3可以帮助早期检测慢性牙周炎和CKD.
- 这一发现突显了Gal-3在治疗这些炎症状况的患者中的潜力.
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