基础过量与败血症老年人死亡率之间的关联
Qiang Zhou1, Yuxiu Miao2, Fenghua Li3
1Department of Orthopedic Surgery, Hekou District People's Hospital, Dongying City, China.
Geriatrics & gerontology international
|January 20, 2025
概括
患有败血症的老年人基础过量 (BE) 显示了与死亡率的U形关联. 高和低的BE水平都会增加死亡风险,强调监测酸平衡的重要性.
科学领域:
- 老年医学 老年医学
- 关键护理医学 关键护理医学
- 生物化学 生化学
背景情况:
- 败血症的老年人面临着高死亡率.
- 酸状态,以过量 (BE) 表示,是败血症的潜在预后标志物.
研究的目的:
- 为了研究基础过量 (BE) 与老年人患有败血症的死亡率之间的关联.
- 探索BE在这个脆弱人群中的预后价值.
主要方法:
- 来自MIMIC-IV数据库的败血症老年人 (≥65岁) 的回顾性分析.
- 使用多变量考克斯回归和卡普兰-梅尔分析评估30天死亡率.
- 检查值效应,使用两段线性回归模型与平滑的曲线拟合.
主要成果:
- 总共有7379名参与者被纳入,30天死亡率为21.8%.
- 在BE和30天死亡率 (P < 0.001) 之间发现了显著的U形关系.
- 较高和较低的BE水平都与增加的死亡风险有关,其拐点为0.5mEq/L.
结论:
- 在白血病和败血症老年人死亡率之间存在U形关系.
- 监测酸状态,特别是BE,对于老年人败血症管理至关重要.
- 在这种患者群体中,BE可以作为死亡率的重要预后标志物.
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