在轻度认知障碍患者的干预中开发一个核心结果集:研究协议.
Victoria Grace Gabb1,2,3, Sam Harding4, Angus G K McNair5,6
1ReMemBr Group, Bristol Medical School, University of Bristol, Bristol, UK victoria.gabb@bristol.ac.uk.
BMJ open
|January 20, 2025
概括
由于指导和干预措施有限,为轻度认知障碍 (MCI) 制定核心结果集 (COS) 是至关重要的. 本研究旨在为研究和临床实践建立标准化的COS,改善MCI患者的护理途径.
科学领域:
- 神经学 神经学
- 老年学是指老年学的学科.
- 临床研究方法论 临床研究方法论
背景情况:
- 轻度认知障碍 (MCI) 缺乏标准化的国家临床管理指南和治疗干预措施.
- 了解患者重要结果对于改善临床研究影响和开发MCI有效护理途径至关重要.
研究的目的:
- 为患有轻度认知障碍 (MCI) 的成年人制定一个核心结果集 (COS).
- 该COS将用于干预研究和临床实践环境,以标准化结果测量.
主要方法:
- 将采用五个阶段的研究设计:系统的文献搜索,定性访谈,证据综合,两轮德尔菲调查和共识会议.
- 对MCI干预研究的综合审查将确定结果,并通过与利益相关方 (患者,家庭,专业人员) 的定性访谈来补充.
- 结果将被综合成一个长列表,然后是德尔菲调查和共识会议,以最终确定COS.
主要成果:
- 该研究目前处于方法开发阶段.
- 伦敦皇后广场研究伦理委员会获得了道德批准.
- 患者和公众参与是COS开发过程的组成部分.
结论:
- 开发MCI的COS是改善研究一致性和临床护理的关键一步.
- 标准化结果将提高评估干预措施的能力,并为MCI制定有效的管理策略.
- 通过出版物,会议和公共道传播结果将确保广泛的影响.
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