一项嵌套的病例对照研究,评估了加拿大老龄化纵向研究中不良童年经历和免疫媒介炎症疾病之间的关系
Julia O'Mahony1,2, Charles N Bernstein3, Ruth Ann Marrie4,5
1Mellen Center, Cleveland Clinic, Cleveland, Ohio, USA omahonj@ccf.org.
BMJ open
|January 20, 2025
概括
儿童不良经历 (ACE) 是常见的,并且与免疫媒介炎症疾病 (IMID) 和其他慢性疾病的更高风险有关. 这包括类风湿性关节炎和多发性硬化症等疾病.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 心理学 心理学 心理学
背景情况:
- 儿童不良经历 (ACE) 与免疫媒介炎症疾病 (IMID) 有着不一致的联系.
- 了解ACE与各种慢性疾病之间的关系对于公共卫生至关重要.
- 以前的研究并没有明确区分ACE对IMID的影响与其他慢性疾病的影响.
研究的目的:
- 调查ACE与患IMID的风险之间的关联.
- 为了比较ACE与IMID与其他慢性疾病 (包括糖尿病,和喘) 的相关性.
- 检查ACE的关联是否在特定的IMID (如多发性硬化症,类风湿性关节炎和炎症性肠病) 中有所不同.
主要方法:
- 使用加拿大老龄化纵向研究 (CLSA) 的数据进行了一项嵌套的回顾性病例控制研究.
- 包括12,627名年龄在45-85岁之间的参与者,他们被诊断为IMID,糖尿病,,喘或没有慢性疾病.
- 评估ACE,包括童年虐待和家庭功能障碍,使用验证的问卷进行评估.
主要成果:
- 64%的参与者报告虐待或家庭功能障碍;30%的人经历了两者.
- 任何虐待,性虐待,家庭功能障碍或多种ACE类型的病史与IMID风险增加有关.
- 在多发性硬化症,类风湿性关节炎和炎症性肠病中,ACE和IMID之间的关联没有显著差异.
结论:
- 在加拿大人口中,不良童年经历很普遍,影响了患有和没有慢性疾病的个人.
- 虐待或家庭功能障碍的病史与慢性疾病发展的风险增加有显著关联.
- 这些发现强调了童年逆境对健康的长期影响,并强调了针对性干预的必要性.
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