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来自大鼠下背和四肢肌肉的感觉输入的中央投射

Ulrich Hoheisel¹, Rolf-Detlef Treede^1,2, Siegfried Mense¹

¹Department of Neurophysiology, Mannheim Center for Translational Neurosciences, Ruprecht- Karls-University Heidelberg, 68167, Mannheim, Germany.

Scientific reports

|January 20, 2025

概括

来自腰部肌肉的疼痛信号与四肢肌肉的疼痛信号不同. 这种脊柱和脊柱上路径的分歧可能解释了各种慢性肌肉疼痛经历.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
身体的感官处理身体的感官处理

背景情况:

从下背部和四肢的慢性肌肉疼痛呈现出明显的临床特征,包括疼痛的流行率和感觉质量.
这些差异表明,从脊髓和大脑内的这些不同的肌肉群中处理 nociceptive 信息的途径可能有所不同.

研究的目的:

为了研究一种假设,即 nociceptive投射路径在腰部肌肉和四肢肌肉之间有所不同.
阐明涉及处理来自多体 (下背部) 和胃半体 (四肢) 的肌肉疼痛的脊柱和脊柱上回路.

主要方法:

利用c-Fos免疫组织化学来识别激活的背角 (DH) 神经元,在注射甲素到多肌 (MF) 或胃半肌 (GS) 肌肉后.
使用金 (FG) 进行逆行标记,以追踪从DH到腹侧周水道灰色 (vlPAG) 和胸膜腹侧侧核 (VPL) 的神经元投射.
分析了双标记的神经元 (c-Fos和FG) 来识别对vlPAG和VPL的感知投影神经元.

主要成果:

接收MF输入的DH神经元位于侧面的I-II层 (Th12-L5),而GS输入神经元位于I-II层 (L3-L5) 的中间,反映了体型.
发射vlPAG的神经元来自表面的DH,而发射VPL的神经元位于深层的DH.
与GS输入相比,来自MF的nociceptive输入涉及更大范围的脊柱段用于脊柱上投射.

结论:

来自腰部肌肉的 nociceptive 输入是整合在脊髓中的更广泛的尾部范围,而不是来自四肢肌肉的输入.
这些独特的脊柱处理模式和随后的投射到PAG和丘脑可能有助于腰部和四肢肌肉疼痛的差异性临床特征.

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