围产期抗生素管理的系统审查 - 我们在哪里,去哪里?
Cristina Winteler1, Sara Ardabili2, Markus Hodel2
1Faculty of Health Science and Medicine, University of Lucerne, Lucerne, Switzerland.
概括
在围产期减少抗生素的使用是可能的,36项研究中的33项研究表明. 需要更多关于抗微生物药物管理 (AMS) 和其对母亲和婴儿健康的影响的研究.
科学领域:
- 产周医学 产周医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 围产期的高抗生素暴露,增加了对抗菌素耐药性 (AMR) 和长期健康的担忧.
- 有效的抗微生物药物管理 (AMS) 对于减轻这些风险至关重要.
研究的目的:
- 系统地审查有关围产期 (2000-2022) AMS 的现有证据.
- 为未来关于围产期抗生素使用和管理的研究确定知识差距.
主要方法:
- 从2000年到2022年,对36项研究进行了全面的系统审查.
- 包括来自美洲,欧洲,亚洲和澳大利亚的数据,包括64,798名孕妇和84,137名新生儿.
主要成果:
- 在36项研究中,有33项报告成功减少了抗生素使用.
- 显示了减少围产期整体抗生素暴露的显著潜力.
结论:
- 虽然减少抗生素使用是可以实现的,但在产前/产后AMS和来自低收入和中等收入国家的研究中存在差距.
- 未来的研究应该专注于前性研究,以安全性,临床和AMR结果.
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