临床前 in ovo PET/MRI 的定量准确性:减弱和量化方法的影响
Theresa Balber1,2, Katarína Benčurová1,2, Manuela Mayrhofer3
1Joint Applied Medicinal Radiochemistry Facility, University of Vienna, Medical University of Vienna, Vienna, Austria.
EJNMMI physics
|January 20, 2025
概括
在卵子成像中,在临床前PET/MRI中进行准确的量化,需要考虑卵子的自我衰减. 补偿这种衰减可以确保可靠的结果,即使不包括MRI硬件在校正中.
科学领域:
- 临床前成像研究研究.
- 核医学和分子成像技术
- 发育生物学和胚胎学
背景情况:
- 混合正子发射断层扫描/磁共振成像 (PET/MRI) 提供先进的临床前成像能力.
- 使用受精蛋的in ovo模型对于研究药物分布和生物过程非常有价值.
- 在卵内PET/MRI的定量准确性受到来自卵和MRI硬件的衰减的挑战.
研究的目的:
- 调查不同衰减源对卵内PET/MRI量化的影响.
- 为了评估基于MRI的减弱校正 (AC) 在卵子实验中的准确性.
- 为了确定可靠的卵内PET/MRI研究的最佳AC策略.
主要方法:
- 在临床前的PET/MRI系统中使用了一种定制的蛋幻影.
- 执行了带有和没有MRI硬件的PET采集,使用不同的AC策略.
- 使用幻影研究和在卵内成像用放射性追踪剂[18F]FDG和[68Ga]Ga-Pentixafor进行定量准确性评估.
主要成果:
- 由于未能对蛋自我减弱和硬件减弱进行校正,导致信号低估 (~49%).
- 对所有衰减源实施全面的交流,实现了准确的量化 (在2%的偏移范围内).
- 使用每公升注射剂量的百分比 (%ID/cc) 的量化可靠,当纠正蛋自衰减时,无论硬件AC是否包含.
结论:
- 卵子自我减弱和MRI硬件都显著影响了 in ovo PET/MRI 中的定量准确性.
- 通过对卵子自我衰减进行校正,可以实现准确的量化,即使MRI硬件衰减没有明确纠正.
- 这凸显了解决量化 in ovo PET/MRI 中对象特异性衰减的关键重要性.
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