便隐性血液影响结直肠癌中的肠道微生物社区结构
Wu Guodong1, Wu Yinhang1,2,3, Wu Xinyue1,2,3
1Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, No.1558 Sanhuan North Road, Wuxing District, Huzhou, Zhejiang Province, 313000, People's Republic of China.
BMC microbiology
|January 20, 2025
概括
便隐性血液测试 (FOBT) 影响肠道微生物的组成. 在结直肠癌 (CRC) 风险预测模型中包括FOBT结果显著提高了准确性,突出了其对早期检测策略的重要性.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
背景情况:
- 肠道微生物群在结直肠癌 (CRC) 风险预测中发挥着作用.
- 便隐性血液检测 (FOBT) 是一种标准的CRC查方法.
研究的目的:
- 调查FOBT对肠道微生物组成的影响.
- 评估FOBT对CRC风险预测模型的影响.
主要方法:
- 来自健康人和CRC患者的便样本的16S核糖体RNA测序.
- 基于FOBT结果的肠道微生物社区结构和多样性的分析.
- 使用机器学习算法开发和比较CRC风险预测模型,使用或不使用FOBT数据.
主要成果:
- 肠道微生物群的组成在健康个体和CRC患者之间有所不同.
- 在FOBT阴性和FOBT阳性CRC患者之间没有观察到显著的多样性差异.
- 当纳入FOBT数据时,CRC风险预测模型的准确性从89.71%增加到92%.
结论:
- FOBT影响了肠道微生物的社区组成.
- 将FOBT状态纳入基于肠道微生物组的CRC风险预测模型可以提高预测准确度.
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