双相情感障碍患者中klotho,神经营养因子 (BDNF,NGF,GDNF) 和认知功能之间的关系
Zeynep Çelebi1, Esra Yazıcı2, Derya Güzel Erdoğan3
1Medical Faculty Department of Psychiatry, Sakarya University, Sakarya, Türkiye.
BMC psychiatry
|January 20, 2025
概括
双极性障碍患者的克洛托和神经生长因子 (NGF) 水平较低. 这些因素,以及来自大脑的神经营养因子 (BDNF),与双相情感障碍的认知功能有关.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 精神病学是一个精神病学.
背景情况:
- 克洛托和神经变因子 (BDNF,NGF,GDNF) 都与认知功能有关.
- 以前的研究还没有同时研究这些分子及其在双相情感障碍 (BD) 中的相互作用.
研究的目的:
- 研究在缓解期间患有双相情感障碍的患者的认知功能,klotho和神经营养因子之间的关系.
- 在BD的认知表现的背景下,评估klotho和神经营养因子之间的潜在相互作用.
主要方法:
- 将男性BD患者 (n=48) 纳入缓解和健康对照 (n=48) 中.
- 使用Stroop测试和韦克斯勒记忆量表进行认知评估.
- 通过ELISA测量血清中klotho,BDNF,GDNF和NGF水平.
主要成果:
- 与对照组相比,BD患者的克洛托和NGF血清水平显著降低.
- 在BD患者中,klotho和NGF水平之间发现了正相关性.
- 在BD患者中,NGF水平与GDNF水平有负相关性.
- 克洛托和NGF预测了韦克斯勒测试的表现;克洛托和BDNF预测了斯特罗普测试的表现.
结论:
- 克洛托,BDNF,GDNF和NGF与BD患者的认知功能有关.
- 在BD患者中观察到这些分子的差异表明一种复杂的调节系统,而不是简单的血清水平变化.
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