基于生育欲望的服务对艾滋病毒血清转换在血清异调伴侣之间的影响:一项为期12年的回顾性队列研究
Bin Yu1,2,3, Chunnong Jike4, Xiaomei Lan4
1Institute for Disaster Management and Reconstruction, Sichuan University-the Hong Kong Polytechnic University, Chengdu, Sichuan, China.
Journal of acquired immune deficiency syndromes (1999)
|January 21, 2025
概括
以理论为指导的生育欲望为基础的服务显著降低了高流行地区夫妇之间的艾滋病毒传播风险. 这种方法利用扩展的信息-动机-行为技能模型,为预防艾滋病毒提供了一个有希望的策略.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 行为科学 行为科学
背景情况:
- 关于减轻艾滋病毒传播风险的基于生育欲望的服务的证据有限.
- 中国的高艾滋病毒流行率和对生育的文化重视,需要有效的预防策略.
研究的目的:
- 检查理论引导的基于欲望的生育服务对艾滋病毒血清转换的长期影响.
- 评估这些服务对高艾滋病毒患病率环境中的血清阳性和血清阴性伴侣的影响.
主要方法:
- 在中国的梁山建立了8653名血清阳性/血清阴性伴侣的回顾性队列 (2009-2020年).
- 扩展信息-动机-行为技能模型引导生育基于欲望的服务.
- 用多变量和逆概率权重调整的考克斯回归模型来估计HIV血清转化风险.
主要成果:
- 92.0%的参与者接受了基于生育欲望的服务.
- 非服务组的HIV血清转化发生率为7.4/1000人/年,而服务组的3.4/1000人/年.
- 服务显著降低了艾滋病毒血清转化风险 (HR=0.32和HR=0.48),在男性和老年人中显示出更大的效果.
结论:
- 理论引导的生育基于欲望的服务显示出降低艾滋病毒传播风险的潜力.
- 扩展的信息-动机-行为技能模型为夫妇有效预防艾滋病毒提供了一个框架.
- 这些服务在艾滋病毒发病率高的地区尤其有益,这些地区的文化重视生育.
更多相关视频
13:58Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
31.5K
19:57An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
18.5K
相关概念视频
Retrovirus Life Cycles
45.6K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.6K
Infertility in Males
240
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
240
Oogenesis
63.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.4K
Sexually Transmitted Infections
262
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
262
Infertility in Females
273
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
273
Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K
